Okayama University Department of Tissue Function Repair

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Research Results

107

Stem Cell Research & Therapy, 2022.

Establishment of a human pluripotent stem cell-derived MKX-tdTomato reporter system.

Yuki Fujisawa, Lu Ming, Daisuke Yamada, Tomoka Takao, Takeshi Takarada (corresponding author) (2022)

106

Biomed Mater, 2022.

Fabrication of scaffold-free mesenchyme tissue bands by cell self-aggregation technique for potential use in tissue regeneration.

Tomoyuki Ota, Ryosuke Iwai, Yohei Kitaguchi, Takeshi Takarada, Yoshihiro Kimata. (2022)

105

STAR Protocols, 2022.

A protocol to induce expandable limb bud mesenchymal cells from human pluripotent stem cells.

Tomoka Takao, Daisuke Yamada, Takeshi Takarada (corresponding author) (2022)

104

Calcif Tissue Int, doi: 10.1007/s00223-022-00997-7.

Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling.

Haoze Yuan, Mika Ikegame, Yoko Fukuhara, Fumiko Takemoto, Yaqiong Yu, Jumpei Teramachi, Yao Weng, Jiajie Guo, Daisuke Yamada, Takeshi Takarada, Ying Li , Hirohiko Okamura, Bin Zhang. (2022)

103

Int. J. Mol. Sci. 23(5), 2661; doi: 10.3390/ijms23052661.

Identification of Surface Antigens That Define Human Pluripotent Stem Cell-Derived PRRX1+Limb-Bud-like Mesenchymal Cells.

Daisuke Yamada, Tomoka Takao, Masahiro Nakamura, Toki Kitano, Eiji Nakata, Takeshi Takarada (corresponding author). (2022)

102

Biofactors, 2021.

O-GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics-oriented study.

Yao Weng, Ziyi Wang, Yoko Fukuhara, Airi Tanai, Mika Ikegame, Daisuke Yamada, Takeshi Takarada, Takashi Izawa, Satoru Hayano, Kaya Yoshida, Hiroshi Kamioka, Hirohiko Okamura. (2021)

101

Acta Med Okayama, 2021.

Mouse Model for Optogenetic Genome Engineering.

Tomoka Takao, Daisuke Yamada, Takeshi Takarada (corresponding author)(2021)

100

Nature Biomedical Engineering, 2021.

Induction and expansion of human PRRX1+ limb-bud-like mesenchymal cells from pluripotent stem cells.

Daisuke Yamada, Masahiro Nakamura, Tomoka Takao, Shota Takihira, Aki Yoshida, Shunsuke Kawai, A kihiro Miura, Lu Ming, Hiroyuki Yoshitomi, Mai Gozu, Kumi Okamoto, Hironori Hojo, Naoyuki Kusaka, Ryosuke Iwai, Eiji Nakata, Toshifumi Ozaki, Junya Toguchida, Takeshi Takarada (corresponding author). (2021)

099

International Journal of Cancer, 2021.

Oncogenic potential of human pluripotent stem cell-derived lung organoids with HER2 overexpression.

Akihiro Miura, Daisuke Yamada, Masahiro Nakamura, Shuta Tomida, Dai Shimizu, Yan Jiang, Tomoka Takao, Hiromasa Yamamoto, Ken Suzawa, Kazuhiko Shien, Masaomi Yamane, Masakiyo Sakaguchi, Shinichi Toyooka#, Takeshi Takarada# (#corresponding author) (2021)

098

Journal of Clinical Investigation, 2021.

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia.

Filip Matthijssens*, Nitesh D. Sharma*, Monique Nysus, Christian K. Nickl, Huining Kang, Dominique R. Perez, Beatrice Lintermans, Wouter Van Loocke, Juliette Roels, Sofie Peirs, Lisa Demoen, Tim Pieters, Lindy Reunes, Tim Lammens, Barbara De Moerloose, Filip Van Nieuwerburgh, Dieter Deforce, Laurence C. Cheung, Rishi S. Kotecha, Martijn Risseeuw, Serge Calenbergh, Takeshi Takarada, Yukio Yoneda, Frederik Van Delft, Richard Lock, Seth Merkley, Alexandre Chigaev, Larry A. Sklar, Charles G. Mullighan, Mignon L. Loh, Stuart S. Winter, Stephen P. Hunger, Steven Goossens, Eliseo Castillo, Wojciech Ornatowski, Pieter Van Vlierberghe, Ksenia Matlawska-Wasowska. (2021)

097

Translational Oncology, 2021.

PRRX1 promotes malignant properties in human osteosarcoma.

Ryoji Joko, Daisuke Yamada, Masahiro Nakamura, Aki Yoshida, Shota Takihira, Tomoka Takao, Ming Lu, Kohei Sato, Tatsuo Ito, Toshiyuki Kunisada, Eiji Nakata, Toshifumi Ozaki, Takeshi Takarada (corresponding author)(2021)

096

Int J Mol Sci, 2020.

B MP-2/β-TCP Local Delivery for Bone Regeneration in MRONJ-Like Mouse Model.

Akihiro Mikai, Mitsuaki Ono, Ikue Tosa, Ha Thi Thu Nguyen, Emilio Satoshi Hara, Shuji Nosho, Aya Ono-Kimura, Kumiko Nawachi, Takeshi Takarada, Takuo Kuboki and Toshitaka Oohashi (2020)

095

Nature Commun, 2020.

A novel RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.

Jung-Min Kim , Yeon-Suk Yang , Kwang Hwan Park , Xianpeng Ge , Ren Xu , Na Li, Minkyung Song , Hyunho Chun , Seoyeon Bok , Julia F. Charles , Odile Filhl-Cochet, Brigitte Boldyreff , Teresa Dinter, Paul B. Yu, Ning Kon, Wei Gu, Takeshi Takarada, Matthew B. Greenblatt, and Jae-Hyuck Shim. (2020)

094

Sci. Rep. 2020.

Core Binding Factors are essential for ovulation, luteinization, and female fertility in mice.

Somang Lee-Thacker, Hayce Jeon, Yohan Choi, Ichiro Taniuchi, Takeshi Takarada, Yukio Yoneda, CheMyong Ko, Misung Jo (2020)

093

Biophys. Res. Commun, 2020.

Establishment of a tTA-dependent photoactivatable Cre recombinase knock-in mouse model for optogenetic genome engineering.

Tomoka Takao, Yuichi Hiraoka, Kenji Kawabe, Daisuke Yamada, Lu Ming, Kohichi Tanaka, Moritoshi Sato, Takeshi Takarada (corresponding author)(2020)

092

Communications Biology, 2019.

I nhibition of the glutamine transporter SNAT1 confers neuroprotection by modulating the mTOR-autophagy system.

Daisuke Yamada, Kenji Kawabe, Ikue Tosa, Shunpei Tsukamoto, Ryota Nakazato, Miki Kou, Koichi Fujikawa, Saki Nakamura, Mitsuaki Ono, Toshitaka Oohashi, Mari Kaneko, Shioi Go, Eiichi Hinoi, Yukio Yoneda and Takeshi Takarada (corresponding author) (2019)

091

Biochem. Biophys. Res. Commun. 2019.

P ostnatal Runx2 deletion leads to low bone mass and adipocyte accumulation in mice bone tissues.

Ikue Tosa, Daisuke Yamada, Misa Yasumatsu, Eiichi Hinoi, Mitsuaki Ono, Toshitaka Oohashi, Takuo Kuboki and Takeshi Takarada (corresponding author)(2019)

090

Biochem. Biophys. Res. Commun. 2019.

Runx2 function in cells of neural crest origin during intramembranous ossification. Biochem.

Yukako Shirai, Kenji Kawabe, Ikue Tosa, Shunpei Tsukamoto, Daisuke Yamadaand Takeshi Takarada (corresponding author) (2019)

089

Addict Biol, 2019.

Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.

Tong Zhang, Junko Yanagida, Hironori Kamii, Shintaro Wada, Masaki Domoto, Hitoki Sasase, Satoshi Deyama, Takeshi Takarada, Eiichi Hinoi, Kenji Sakimura, Akihiro Yamanaka, Takashi Maejima, Michihiro Mieda, Takeshi Sakurai, Naoya Nishitani, Kazuki Nagayasu, Shuji Kaneko, Masabumi Minami, Katsuyuki Kaneda (2019)

[89] Tong Zhang, Junko Yanagida, Hironori Kamii, Shintaro Wada, Masaki Domoto, Hitoki Sasase, Satoshi Deyama, Takeshi Takarada, Eiichi Hinoi, Kenji Sakimura, Akihiro Yamanaka, Takashi Maejima, Michihiro Mieda, Takeshi Sakurai, Naoya Nishitani, Kazuki Nagayasu, Shuji Kaneko, Masabumi Minami, Katsuyuki Kaneda (2019) Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice. Addict Biol, in press.

[88] Nurmaya Effendi#, Kenji Mishiro#, Takeshi Takarada, Daisuke Yamada, Ryuichi Nishii, Kazuhiro Shiba, Seigo Kinuya, Akira Odani, Kazuma Ogawa (2018) Design, synthesis, and biological evaluation of radioiodinated benzo[d]imidazole-quinoline derivatives for platelet-derived growth factor receptor β (PDGFRβ) imaging. Bioorg Med Chem, in press.

[87] Ha Thi Nguyen, Mitsuaki Ono, Yasutaka Oida, Emilio Satoshi Hara, Taishi Komori, Kentaro Akiyama, Ha Thi Thu Nguyen, Kyu Thu Aung, Hai Thanh Pham, Ikue Tosa, Takeshi Takarada, Koichi Matsuo, Toshihide Mizoguchi, Toshitaka Oohashi, Takuo Kuboki (2018) Bone marrow cells inhibit BMP-2-induced osteoblast activity in the marrow environment. J. Bone Miner. Res. in press.

[86] Daisuke Yamada, Koichi Fujikawa, Kenji Kawabe, Takuya Furuta, Mitsutoshi Nakada, Takeshi Takarada (corresponding author) (2018) RUNX2 promotes malignant progression in glioma. Neurochem. Res. in press.

[85] Lifan Liao, Hua Jiang, Yunshan Fan, Ronald Siyi Lu, Changli Wei, Takeshi Takarada, Shisheng He, and Di Chen (2018) Runx2 Is Required for Postnatal Intervertebral Disc Tissue Growth and Development. J. Cell. Physiol. In press.

[84] Nurmaya Effendi#, Kenji Mishiro#, T akeshi Takarada, Akira Makino, Daisuke Yamada, Yoji Kitamura, Kazuhiro Shiba, Yasushi Kiyono, Akira Odani, Kazuma Ogawa (2018) Radiobrominated benzimidazole-quinoline derivatives as Platelet-derived growth factor receptor beta (PDGFRβ) imaging probes.Sci. Rep. in press.

[83] Takashi Iezaki, Kazuya Fukasawa, Tetsuhiro Horie, Gyujin Park, Samuel Robinson, Michio Nakaya, Hiroyuki Fujita, Yuki Onishi, Kakeru Ozaki, Takashi Kanayama, Manami Hiraiwa, Yuka Kitaguchi, Katsuyuki Kaneda, Yukio Yoneda, Takashi Takarada, X. Edward Guo, Hitoshi Kurose and Eiichi Hinoi (2018) The MAPK Erk5 is necessary for proper skeletogenesis through a molecular axis that involves Smurfs-Smads-Sox9.Development, in press.

[82] Somang Lee-Thacker, Yohan Choi, Ichiro Taniuchi, T akeshi Takarada, CheMyong Ko, Misung Jo (2018) Core Binding Factorβ expression in ovarian granulosa cells is essential for female fertility. Endocrinology, 159, 2094-2109.

[81] Taishi Komori, Mitsuaki Ono, Emilio Satoshi Hara, Junji Ueda, Ha Thi Thu Nguyen, Ha Thi Nguyen, Tomoko Yonezawa, Takahiro Maeba, Aya Ono, Takeshi Takarada, Ryusuke Momota, Kenji Maekawa, Takuo Kuboki, Toshitaka Oohashi (2018) Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium. Sci. Rep. 8, 2612..

[80] Takanori Ishikawa, Takashi Nishida, Mitsuaki Ono, Takeshi Takarada, Nguyen Ha, Shinnosuke Kurihara, Takayuki Furumatsu, Yurika Murase, Masaharu Takigawa, Toshitaka Oohashi, Hiroshi Kamioka, Satoshi Kubota (2018) Physiological role of urothelial cancer-associated 1 long noncoding RNA in human skeletogenic cell differentiation. J. Cell. Physiol. 233, 4825-4840.

[79] Ryota Nakazato, Kenji Kawabe, Daisuke Yamada, Shinsuke Ikeno, Michihiro Mieda, Shigeki Shimba, Eiichi Hinoi, Yukio Yoneda and Takeshi Takarada (corresponding author) (2017) Disruption of Bmal1 impairs blood–brain barrier integrity via pericyte dysfunction.J. Neurosci. 37, 10052-10062.

[78] Nurmaya Effendi, Kazuma Ogawa, Kenji Mishiro, Takeshi Takarada, Daisuke Yamada, Yoji Kitamurae, Kazuhiro Shibae, Takehiko Maeda, Akira Odani (2017) Synthesis and evaluation of 125I-labeled 1-[2-[5-(2-methoxyethoxy)-1H-benzo[d]imidazol-1-yl]quinolin-8-yl]piperidin-4-amine derivatives for platelet-derived growth factor receptor β (PDGFRβ) imaging. Bioorg Med Chem, in press.

[77] Lifan Liao, Shanxing Zhang, Jianhong Gu, Weiwei Zhao, Takeshi Takarada, Yukio Yoneda, Jian Huang, Lan Zhao, Chun-do Oh, Jun Li, Mei-qing Wang, and Di Chen (2017) Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice. Sci. Rep. 7, 1:2371.

[76] Gyujin Park, Tetsuhiro Horie, Takashi Kanayama, Kazuya Fukasawa, Takashi Iezaki, Yuki Onishi, Kakeru Ozaki, Yukari Nakamura, Yukio Yoneda, Takeshi Takarada and Eiichi Hinoi. (2017) The transcriptional modulator Ifrd1 controls PGC-1α expression under short-term adrenergic stimulation in brown adipocytes. FEBS J. 284, 784-795.

[75] Takeshi Takarada (corresponding author), Cheng Xu, Hiroki Ochi, Ryota Nakazato, Daisuke Yamada, Saki Nakamura, Ayumi Kodama, Shigeki Shimba, Michihiro Mieda, Kazuya Fukasawa, Kakeru Ozaki, Takashi Iezaki, Koichi Fujikawa, Yukio Yoneda, Rika Numano, Akiko Hida, Hajime Tei, Shu Takeda and Eiichi Hinoi (2017) Bone resorption is regulated by circadian clock in osteoblasts.J. Bone Miner. Res. 32, 872-881.

[74] Ryota Nakazato, Shogo Hotta, Daisuke Yamada, Miki Kou, Saki Nakamura, Yoshifumi Takahata, Hajime Tei, Rika Numano, Akiko Hida, Shigeki Shimba, Michihiro Mieda, Eiichi Hinoi, Yukio Yoneda and Takeshi Takarada (corresponding author) (2016) The intrinsic microglial clock system regulates interleukin-6 expression. Glia 65, 198-208.

[73] Takashi Iezaki, Kazuya Fukasawa, Gyujin Park, Tetsuhiro Horie, Takashi Kanayama, Kakeru Ozaki, Yuki Onishi, Yoshifumi Takahata, Yukari Nakamura, Takeshi Takarada, Yukio Yoneda, Takashi Nakamura, Jean Vacher and Eiichi Hinoi (2016) The transcriptional modulator Ifrd1 regulates osteoclast differentiation through enhancing NF-κB/NFATc1 pathway. Mol. Cell. Biol. 36, 2451-2463.

[72] Takeshi Takarada, Noritaka Nakamichi, Ryota Nakazato, Takami Kakuda, Hiroshi Kokubo, Shinsuke Ikeno, Saki Nakamura, Nobuyuki Kuramoto, Eiichi Hinoi and Yukio Yoneda (2016) Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells in vitro. Biochem. Biophys. Rep. 5, 89-95.

[71] Takeshi Takarada, Masato Ogura, Noritaka Nakamichi, Takami Kakuda, Ryota Nakazato, Hiroshi Kokubo, Shinsuke Ikeno, Saki Nakamura, Takaya Kutsukake, Eiichi Hinoi and Yukio Yoneda (2016) Upregulation of Slc38a1 gene along with promotion of neurosphere growth and subsequent neuronal specification in undifferentiated neural progenitor cells exposed to theanine. Neurochem. Res. 41, 5-15.

[70] Takashi Iezaki, Yuki Onishi, Kakeru Ozaki, Kazuya Fukasawa, Yoshifumi Takahata, Yukari Nakamura, Koichi Fujikawa, Takeshi Takarada, Yukio Yoneda, Yui Yamashita, Go Shioi and Eiichi Hinoi (2016) The transcriptional modulator interferon-related developmental regulator 1 in osteoblasts suppresses bone formation and promotes bone resorption.J. Bone Miner. Res., 31, 573-584.

[69] Takeshi Takarada (corresponding author), Ryota Nakazato, Azusa Tsuchikane, Koichi Fujikawa, Takashi Iezaki, Yukio Yoneda, Eiichi Hinoi (2016) Genetic analysis of Runx2 function during intramembranous ossification.Development, 143, 211-218.

[68] Takeshi Takarada (corresponding author), Miki Kou, Miho Hida, Ryo Fukumori; Saki Nakamura, Takaya Kutsukake, Nobuyuki Kuramoto, Eiichi Hinoi and Yukio Yoneda (2016) Protective upregulation of activating transcription factor-3 against glutamate neurotoxicity in neuronal cells under ischemia.J. Neurosci. Res. 94, 378-388.

[67] Cheng Xu, Hiroki Ochi, Toru Fukuda, Shingo Sato, Satoko Sunamura, Takeshi Takarada, Eiichi Hinoi, Atsushi Okawa and Shu Takeda (2016) Circadian clock regulates bone resorption in mice. J. Bone Miner. Res. 31, 1344-1355.

[66] Takashi Iezaki, Kakeru Ozaki1, Kazuya Fukasawa, Makoto Inoue, Shigetaka Kitajima, Takeshi Muneta, Shu Takeda, Hiroyuki Fujita, Yuki Onishi, Tetsuhiro Horie, Yukio Yoneda, Takeshi Takaradaand Eiichi Hinoi (2016) ATF3 deficiency in chondrocytes alleviates osteoarthritis development. J. Pathol. 239, 426-37.

[65] Kazuya Fukasawa, Gyujin Park, Takashi Iezaki, Tetsuhiro Horie, Takashi Kanayama, Kakeru Ozaki, Yuki Onishi, Yoshifumi Takahata, Yukio Yoneda, Takeshi Takarada, Shigetaka Kitajima, Jean Vacher and Eiichi Hinoi (2016) ATF3 controls proliferation of osteoclast precursor and bone remodeling. Sci. Rep. 2, 6:30918.

[64] Jianwen Wei, Junko Shimazu, Munevver P. Makinistoglu, Antonio Maurizi, Daisuke Kajimura, Haihong Zong, Takeshi Takarada, Takashi Iezaki, Jeffrey E. Pessin, Eiichi Hinoi and Gerard Karsenty (2015) Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation. Cell, 161, 1576-1591.

[63] Koichi Fujikawa, Ryo Fukumori, Saki Nakamura, Takaya Kutsukake, Takeshi Takaradaand Yukio Yoneda (2015) Potential interactions of calcium-sensitive reagents with zinc ion in different cultured cells. PLoS ONE 10, e0127421.

[62] Ryota Nakazato*, Takeshi Takarada * (*Equally contributed), Shinsuke Ikeno, Saki Nakamura, Takaya Kutsukake, Eiichi Hinoi and Yukio Yoneda (2015) Upregulation of runt-related transcription factor-2 through CCAAT enhancer binding protein-beta signaling pathway in microglial BV-2 cells exposed to ATP. J. Cell. Physiol. 230, 2510-2521.

[61] Takeshi Takarada, Noritaka Nakamichi, Takami Kakuda, Ryota Nakazato, Hiroshi Kokubo, Shinsuke Ikeno, Saki Nakamura, Eiichi Hinoi and Yukio Yoneda (2015) Daily oral intake of theanine prevents the decline of 5-bromo-2′-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress. J Pharmacol Sci. 127, 292-297.

[60] Ryota Nakazato*, Takeshi Takarada * (*Equally contributed), Takumi Watanabe, Binh Thanh Nguyen, Shinsuke Ikeno, Eiichi Hinoi and Yukio Yoneda (2014) Constitutive and functional expression of runt-related transcription factor-2 by microglial cells. Neurochem. Int. 74, 24-35.

[59] Ryo Fukumori*, Takeshi Takarada* (*Equally contributed), Ryota Nakazato, Koichi Fujikawa, Miki Kou, Eiichi Hinoi and Yukio Yoneda (2013) Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons. PLoS ONE 8, e69718.

[58] Nguyen Quynh Le*, Nguyen Thanh Binh*(*Equally contributed), Takeshi Takarada, Mika Takarada-Iemata, Eiichi Hinoi and Yukio Yoneda (2013) A negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells. J. Pharmacol. Sci. 122, 318-325.

[57] Takeshi Takarada*, Miki Kou* (*Equally contributed), Noritaka Nakamichi, Masato Ogura, Yuma Ito, Ryo Fukumori, Hiroshi Kokubo, Gabriela B. Acosta, Eiichi Hinoi and Yukio Yoneda (2013) Myosin VI reduces proliferation, but not differentiation, in pluripotent P19 cells. PLoS ONE 8, e63947.

[56] Takeshi Takarada, Eiichi Hinoi, Ryota Nakazato, Hiroki Ochi, Cheng Xu, Azusa Tsuchikane, Shu Takeda, Gerard Karsenty, Takaya Abe, Hiroshi Kiyonari, and Yukio Yoneda (2013) An analysis of skeletal development in osteoblast- and chondrocyte-specific Runx2 knockout mice. J. Bone Miner. Res. 28, 2064-2069. Commentary by Jane B. Lian, Jonathan A. Gordon and Gary S. Stein. (2013) Redefining the Activities of a Bone – Specific Transcription Factor: Novel Insights for Understanding Bone Formation. J. Bone Miner. Res. 28, 2060-2063.

[55] Masato Ogura*, Takami Kakuda*, Takeshi Takarada*(*Equally contributed), Noritaka Nakamichi, Ryo Fukumori, Yeong-Hun Kim, Eiichi Hinoi and Yukio Yoneda (2012) Promotion of both proliferation and differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter Slc38a1. PLoS ONE 7, e48270.

[54] Takeshi Takarada, Ayumi Kodama, Shogo Hotta, Michihiro Mieda, Shigeki Shimba, Eiichi Hinoi and Yukio Yoneda (2012) Clock genes influence gene expression in growth plate and endochondral ossification in mice. J. Biol. Chem. 287, 36081-36095.

[53] Takeshi Takarada*, Noritaka Nakamichi* (*Equally contributed), Seiya Kitajima, Ryo Fukumori, Ryota Nakazato, Nguyen Quynh Le, Yeong-Hun Kim, Koichi Fujikawa, Miki Kou and Yukio Yoneda (2012) Promoted neuronal differentiation after activation of alpha4/beta2 nicotinic acetylcholine receptors in undifferentiated neural progenitors. PLoS ONE 7, e46177.

[52] Yoshifumi Takahata*, Eiichi Hinoi* (*Equally contributed), Takeshi Takarada, Yukari Nakamura, Shinya Ogawa and Yukio Yoneda (2012) Positive regulation by GABAB receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4. J. Biol. Chem. 287, 33293-33303.

[51] Takeshi Takarada*, Noritaka Nakamichi*, Hirofumi Kawagoe, Masato Ogura, Ryo Fukumori, Ryota Nakazato, Koichi Fujikawa, Miki Kou and Yukio Yoneda (2012) Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial cell line-derived neurotrophic factor in astrocytes. J. Neurosci. Res. 90, 2074-2085. Selected for the cover art.

[50] Ryo Fukumori*, Takeshi Takarada* (*Equally contributed), Yuki Kambe, Ryota Nakazato, Koichi Fujikawa and Yukio Yoneda (2012) Possible involvement of mitochondrial uncoupling protein-2 in cytotoxicity mediated by acquired N-methyl-D-aspartate receptor channels. Neurochem. Int. 61, 498-505.

[49] Hiroyuki Fujita*, Eiichi Hinoi* (*Equally contributed), Eri Nakatani, Tomomi Yamamoto, Takeshi Takaradaand Yukio Yoneda (2012) Possible modulation of process extension by N-methyl-D-aspartate receptor expressed in osteocytic MLO-Y4 cells. J. Pharmacol. Sci. 119, 112-116.

[48] Koichi Fujikawa*, Noritaka Nakamichi* (*Equally contributed), Shunsuke Kato, Ryo Fukumori, Miho Hida, Takeshi Takaradaand Yukio Yoneda (2012) Delayed mitochondrial membrane potential disruption by ATP in cultured rat hippocampal neurons exposed to N-methyl-D-aspartate. J. Pharmacol. Sci. 119, 20-29.

[47] Takeshi Takarada, Mika Takarada-Iemata, Yoshifumi Takahata, Daisuke Yamada, Tomomi Yamamoto, Yukari Nakamura, Eiichi Hinoi and Yukio Yoneda (2012) Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts. J. Cell. Physiol. 227, 3477-3487.

[46] Eiichi Hinoi, Hiroki Ochi, Takeshi Takarada, Eri Nakatani, Takashi Iezaki, Hiroko Nakajima, Hiroyuki Fujita, Yoshifumi Takahata, Shinya Hidano, Takashi Kobayashi, Shu Takeda and Yukio Yoneda (2012) Positive regulation of osteoclastic differentiation by growth differentiation factor-15 up-regulated in osteocytic cells under hypoxia. J. Bone Miner. Res. 27, 938-949.

[45]Yukary Nakamura, Noritaka Nakamichi, Takeshi Takarada, Kiyokazu Ogita and Yukio Yoneda (2012) Transferrin receptor-1 suppresses neurite outgrowth in neuroblastoma Neuro2A cells. Neurochem. Int. 60, 448-457.

[44] Takahisa Gono*, Takeshi Takarada*(*Equally contributed), Ryo Fukumori, Yasushi Kawaguchi, Hirotaka Kaneko, Masanori Hanaoka, Yasuhiro Katsumata, Yukio Yoneda and Hisashi Yamanaka (2011) NR2-reactive antibody decreases cell viability through augmentation of Ca2+ influx in systemic lupus erythematosus. Arthritis Rheum. 63, 3952-3959.


[43] Yoshifumi Takahata*, Takeshi Takarada*(*Equally contributed), Eiichi Hinoi, Yukari Nakamura, Hiroyuki Fujita and Yukio Yoneda (2011) Osteoblastic GABAB receptors negatively regulate osteoblastogenesis toward disturbance of osteoclastogenesis mediated by receptor activator of nuclear factor-kB ligand in mouse bone. J. Biol. Chem. 286, 32906-32917.

[42] Takeshi Takarada, Tomoya Hara, Shiho Konishi, Ryota Nakazato and Yukio Yoneda (2011) Selective downregulation of N-methyl-D-aspartate receptor (NMDAR) rather than non-NMDAR subunits in ipsilateral cerebral hemispheres in rats with middle cerebral artery occlusion. Jpn. J. Neuropsychopharmacol. 31, 187-194.

[41] Ryota Nakazato*, Takeshi Takarada*(*Equally contributed), Tomomi Yamamoto, Shogo Hotta, Eiichi Hinoi and Yukio Yoneda (2011) Selective upregulation of Per1 mRNA expression by ATP through activation of P2X7 purinergic receptors expressed in microglial cells. J. Pharmacol. Sci. 116, 350-361.

[40] Kyosuke Uno, Takeshi Takarada, Mika Takarada-Iemata, Yukari Nakamura, Hiroyuki Fujita, Eiichi Hinoi and Yukio Yoneda (2011) Negative regulation of osteoblastogenesis through downregulation of runt-related transcription factor-2 in osteoblastic MC3T3-E1 cells with stable overexpression of the cystine/glutamate antiporter xCT subunit. J. Cell. Physiol. 226, 2953-2964.

[39] Yuki Kambe, Noritaka Nakamichi, Takeshi Takarada, Ryo Fukumori, Ryota Nakazato, Eiichi Hinoi and Yukio Yoneda (2011) A pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-D-aspartate receptors in cultured rat hippocampal neurons. Neurochem. Int. 59, 10-20.

[38] Yukari Nakamura*, Eiichi Hinoi* (*Equally contributed), Takeshi Takarada, Yoshifumi Takahata, Tomomi Yamamoto, Hiroyuki Fujita, Saya Takada, Syota Hashizume and Yukio Yoneda (2011) Positive regulation by GABABR1 subunit of leptin expression through gene transactivation in adipocytes. PLoS ONE 6, e20167.

[37] Masato Ogura, Takeshi Takarada, Noritaka Nakamichi, Hirofumi Kawagoe, Aya Sako, Ryota Nakazato and Yukio Yoneda (2011) Exacerbated vulnerability to oxidative stress in astrocytic C6 glioma cells with stable overexpression of the glutamine transporter slc38a1. Neurochem. Int. 58, 504-511.

[36] Kyosuke Uno, Takeshi Takarada, Yukari Nakamura, Hiroyuki Fujita, Eiichi Hinoi and Yukio Yoneda (2011) A negative correlation between expression profiles of runt-related transcription factor-2 and cystine/glutamate antiporter xCT subunit in ovariectomized mouse bone. J. Pharmacol. Sci. 115, 309-319.

[35] Masaki Fukui*, Shusuke Ozawa*(*Equally contributed), Noritaka Nakamichi, Ryota Nakazato, Takeshi Takarada and Yukio Yoneda (2011) Gradual downregulation of protein expression of the partner GABABR2 subunit during postnatal brain development in mice defective of GABABR1 subunit. J. Pharmacol. Sci. 115, 45-55.

[34] Mika Takarada-Iemata*, Takeshi Takarada*(*Equally contributed), Yukari Nakamura , Eri Nakatani , Osamu Hori and Yukio Yoneda (2011) Glutamate preferentially suppresses osteoblastogenesis than adipogenesis through the cystine/glutamate antiporter in mesenchymal stem cells. J. Cell. Physiol. 226, 652-665.

[33] Ryo Fukumori, Takeshi Takarada, Noritaka Nakamichi, Yuki Kambe, Hirofumi Kawagoe, Ryota Nakazato and Yukio Yoneda (2010) Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria. Neurochem. Int. 57, 730-737.

[32] Yuki Kambe, Noritaka Nakamichi, Takeshi Takarada, Ryo Fukumori and Yukio Yoneda (2010) Induced tolerance to glutamate neurotoxicity through downregulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons. J. Neurosci. Res. 88, 2177-2187.

[31] Noritaka Nakamichi*, Ryo Fukumori* (*Equally contributed), Takeshi Takarada, Yuki Kambe, Tomomi, Yamamoto, Nobuyuki Matsushima, Nobuaki Moriguchi and Yukio Yoneda (2010) Preferential inhibition by antidiarrheic 2-methoxy-4-methylphenol of Ca2+ influx across acquired N-methyl-D-aspartate receptor channels composed of NR1/NR2B subunit assembly. J. Neurosci. Res. 88, 2483-2493.

[30] Ryo Fukumori*, Noritaka Nakamichi*(*Equally contributed), Takeshi Takarada, Yuki Kambe, Nobuyuki Matsushima, Nobuaki Moriguchi and Yukio Yoneda (2010) Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate receptor channels. J. Pharmacol. Sci. 112, 273-281.

[29] Takeshi Takarada*, Keisuke Tamaki* (*Equally contributed), Toru Takumi, Masato Ogura, Yuma Ito, Noritaka Nakamichi and Yukio Yoneda (2009) A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus. J. Neurochem. 110, 1457-1468.

[28] Takeshi Takarada, Hironori Hojo, Mika Iemata, Koichi Sahara, Ayumi Kodama, Nobuhiro Nakamura, Eiichi Hinoi and Yukio Yoneda (2009) Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members. Bone 45, 568-578.

[27] Takeshi Takarada, Yoshifumi Takahata, Mika Iemata, Eiichi Hinoi, Kyosuke Uno, Takao Hirai, Tomomi Yamamoto and Yukio Yoneda (2009) Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes. J. Cell. Physiol. 220, 756-764.

[26] Noritaka Nakamichi, Yukichi Ishioka, Takao Hirai, Shusuke Ozawa, Masaki Tachibana, Nobuhiro Nakamura, Takeshi Takaradaand Yukio Yoneda (2009) Possible promotion of neuronal differentiation in fetal rat brain neural progenitor cells after sustained exposure to static magnetism. J. Neurosci. Res. 87, 2406-2417.

[25] Yukari Nakamura*, Takeshi Takarada*(*Equally contributed), Ayumi Kodama, Eiichi Hinoi and Yukio Yoneda (2009) Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes. J. Pharmacol. Sci. 109, 413-423.

[24] Takeshi Takaradaand Yukio Yoneda (2009) Transactivation by runt related factor-2 of matrix metalloproteinase-13 in astrocytes. Neurosci. Lett. 451, 99-104.

[23] Bin Gu*, Noritaka Nakamichi* (*Equally contributed), Wen-Sheng Zhang, Yukary Nakamura, Yuki Kambe, Ryo Fukumori, Kazuhiro Takuma, Kiyofumi Yamada, Takeshi Takarada, Hideo Taniura and Yukio Yoneda (2009) Possible protection by notoginsenoside R1 against neurotoxicity of N-methyl-D-aspartate receptor composed of an NR1/NR2B heteromeric assembly. J. Neurosci. Res. 87, 2145-2156.

[22] Yoshifumi Takahata*, Takeshi Takarada*(*Equally contributed), Mika Iemata, Tomomi Yamamoto, Yukary Nakamura, Ayumi Kodama and Yukio Yoneda (2008) Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells. J. Cell. Physiol. 218, 268-275.

[21] Danko D. Georgiev, Hideo Taniura, Yuki Kambe, Takeshi Takaradaand Yukio Yoneda (2008) A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation. Exp. Cell Res. 314, 2603-2617.

[20] Yoshifumi Takahata*, Takeshi Takarada*(*Equally contributed), Masato Osawa, Eiichi Hinoi, Yukari Nakamura and Yukio Yoneda (2008) Differential regulation of cellular maturation in chondrocytes and osteoblasts by glycine. Cell Tissue Res. 333, 91-103.

[19] Takeshi Takarada, Eiichi Hinoi, Yoshifumi Takahata and Yukio Yoneda (2008) Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9-dependent manner. J. Cell. Physiol. 215, 320-328.

[18] Eiichi Hinoi, Takeshi Takarada, Sayumi Fujimori, Liyang Wang, Mika Iemata, Kyosuke Uno and Yukio Yoneda (2007) Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis. Bone 40, 337-344.

[17] Eiichi Hinoi*, Takeshi Takarada*(*Equally contributed), Kyosuke Uno, Maki Inoue, Yashuhiro Murafuji and Yukio Yoneda (2007) Glutamate suppresses osteoclastogenesis through the cystine/glutamate antiporter. Am. J. Pathol. 170, 1277-1290.

[16] Mika Iemata*, Takeshi Takarada*(*Equally contributed), Eiichi Hinoi, Hideo Taniura and Yukio Yoneda (2007) Suppression by glutamate of proliferative activity through glutathione depletion mediated by the cystine/glutamate antiporter in mesenchymal C3H10T1/2 stem cells. J. Cell. Physiol. 213, 721-729.

[15] Nobuaki Moriguchi, Eiichi Hinoi, Takeshi Takarada, Nobuyuki Matsushima, Kyosuke Uno and Yukio Yoneda (2007) Oral administration of phenolic antidiarrheic ingredients prevents ovariectomy-induced bone loss. Biochem. Pharmacol. 73, 385-393.

[14] Takeshi Takarada, Eiichi Hinoi, Yuki Kambe, Koichi Sahara, Shintaro Kurokawa, Yoshifumi Takahata and Yukio Yoneda (2007) Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid. Eur. J. Pharmacol. 575, 1-11.

[13] Kyosuke Uno*, Takeshi Takarada*(*Equally contributed), Eiichi Hinoi and Yukio Yoneda (2007) Glutamate is a determinant of cellular proliferation through modulation of nuclear factor E2 p45-related factor-2 expression in osteoblastic MC3T3-E1 cells. J. Cell. Physiol. 213, 105-114.

[12] Sayumi Fujimori, Eiichi Hinoi, Takeshi Takarada, Mika Iemata, Yoshifumi Takahata and Yukio Yoneda (2006) Possible expression of a particular gamma-aminobutyric acid transporter isoform responsive to upregulation by hyperosmolarity in rat calvarial osteoblasts. Eur. J. Pharmacol. 550, 24-32.

[11] Eiichi Hinoi, Takeshi Takarada, Yuriko Tsuchihashi, Sayumi Fujimori, Nobuaki Moriguchi, Liyang Wang, Kyosuke Uno and Yukio Yoneda (2006) A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol .Pharmacol. 70, 925-935.

[10] Eiichi Hinoi, Taichi Ueshima, Hironori Hojo, Mika Iemata, Takeshi Takarada and Yukio Yoneda (2006) Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes. J. Biol. Chem. 281, 23632-23642.

[9] Nobuaki Moriguchi, Eiichi Hinoi, Yuriko Tsuchihashi, Sayumi Fujimori, Mika Iemata, Takeshi Takaradaand Yukio Yoneda (2006) Cytoprotection by pyruvate through an anti-oxidative mechanism in cultured rat calvarial osteoblasts. Histol. Histopathol. 21, 969-977.

[8] Eiichi Hinoi, Ryosuke Ohashi, Susumu Miyata, Yasuko Kato, Mika Iemata, Hironori Hojo, Takeshi Takaradaand Yukio Yoneda (2005) Excitatory amino acid transporters expressed by synovial fibroblasts in rats with collagen-induced arthritis. Biochem. Pharmacol. 70, 1744-1755.

[7] Takao Hirai, Hideo Taniura, Yasuaki Goto, Keisuke Tamaki, Hirotaka Oikawa, Yuki Kambe, Masato Ogura, Yu Ohno, Takeshi Takarada and Yukio Yoneda (2005) Counteraction by repetitive daily exposure to static magnetism against sustained blockade of N-methyl-D-aspartate receptor channels in cultured rat hippocampal neurons. J. Neurosci. Res. 80, 491-500.

[6] Nobuyuki Kuramoto, Keita Kubo, Kiyokazu Ogita, Jan Platenik, Vladimir J. Balcar, Takeshi Takarada, Noritaka Nakamichi and Yukio Yoneda (2005) Nuclear condensation of cyclic adenosine monophosphate responsive element-binding protein in discrete murine brain structures. J. Neurosci. Res. 80, 667-676.

[5] Liyang Wang, Eiichi Hinoi, Akihiro Takemori, Takeshi Takaradaand Yukio Yoneda (2005) Abolition of chondral mineralization by group III metabotropic glutamate receptors expressed in rodent cartilage. Br. J. Pharmacol. 146, 732-743.

[4] Takeshi Takarada, Eiichi Hinoi, Vladimir J. Balcar, Hideo Taniura and Yukio Yoneda (2004) Possible expression of functional glutamate transporters in the rat testis. J. Endocrinol. 181, 233-244.

[3] Takeshi Takarada, Eiichi Hinoi, Sayumi Fujimori, Yuriko Tsuchihashi, Taichi Ueshima, Hideo Taniura and Yukio Yoneda (2004) Accumulation of [3H] glutamate in cultured rat calvarial osteoblasts. Biochem. Pharmacol. 68, 177-184.

[2] Takeshi Takarada, Vladimir J. Balcar, Katsuhiro Baba, Akiko Takamoto, Gabriela B. Acosta, Katsura Takano and Yukio Yoneda (2003) Uptake of [3H]L-serine in rat brain synaptosomal fractions. Brain Res. 983, 36-47.

[1] Eiichi Hinoi, Sayumi Fujimori, Takeshi Takarada, Hideo Taniura and Yukio Yoneda (2002) Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts. Biochem. Biophys. Res. Commun. 297, 452-458．