In this field, we aim to achieve an integrated, systems-level understanding of the operating principles underlying the human body plan (the blueprint of morphogenesis) by leveraging the stem cell biology framework of hierarchy and lineage. The fundamental principles identified through this approach will be rapidly translated into medical applications by promptly establishing collaborative research structures centered on intramural partnerships—particularly with the university hospital—thereby enabling broad deployment across diverse areas, including regenerative medicine and drug discovery using induced pluripotent stem cells (iPSCs), as well as cancer research.
Our core research methodologies are based on
・differentiation induction studies of human pluripotent stem cells (hESCs and iPSCs) utilizing genome-editing technologies, and
・stem cell biology approaches employing mouse genetics.
In addition to these foundational techniques, we actively incorporate emerging technological developments, such as
・multi-omics analyses using high-performance supercomputing, and
・identification of minor cellular populations through single-cell RNA sequencing.
Below, we present one representative example of this approach.
(1) Regenerative medicine leveraging induced pluripotent stem cells (iPSCs)
(2) Data science–driven research, with a particular focus on multi-omics analyses